Chemical Surveys on Mycotoxins Using Cytotoxicity Testing with Special Reference to Cytochalasans

Abstract

This review describes our surveys on mycotoxins using cytotoxicity testing, chemical studies on new mycotoxins such as terphenyllin, xanthoascin, chaetochromin, cochliodinol isomers, and chaetoglobosins A-G and J, and their toxic effects. Since chaetoglobosins belong to the new type of cytochalasans, present status of chemical and cell biological studies on cytochalasans was mentioned. Our recent observations on the effects of cytochalasans at molecular and cellular levels were also described.