Studies on Pyridinol Derivatives. X. Synthesis and Pharmacological Activity of 4-Acyl-3, 4-dihydro-2H-pyrido [3, 2-b]-1, 4-oxazine Derivatives

Abstract

Twenty kinds of 4-acyl-3, 4-dihydro-2H-pyrido [3, 2-b]-1, 4-oxazine (12a-21b) were synthesized. The following results were obtained by the preliminary investigation on the local anesthetic and the analgesic (mouse writhing test) activities of the synthesized compounds. There was little local anesthetic activity in all these compounds ; there was an analgesic activity approximately equivalent to aspirin's.