Studies of the Experimental Chemotherapy for Dermatomycosis and Candidiasis. IX. On the Antifungal Activity for Various Maleimide and Succinimide Compounds

Abstract

Antifungal activity of eighty-two maleimide and forty-two succinimide compounds against Trichophyton asteroides were examined in vitro. Among these compounds, eleven kinds of N-phenylmaleimides exhibited to have more potent antifungal activity than that of pentachlorophenol as a reference compound. In the N-phenylmaleimides, an increase in the activity was obtained by halogen or alkyl substitutions on the phenyl ring. However, the activity was diminished by halogen or other substitutions at α or α, α'positions on the maleimide ring. The results of therapeutic tests by use of guinea-pigs revealed that a tincture containing 1% N-(2, 6-diethylphenyl) maleimide had 57.7% of cure rate on experimental trichophytosis.