3-Arylamino-2-dialkylaminomethyl-4,4-dimethyl-2-buten-4-olide及びそのAza誘導体の合成

松尾 圭造; 太田 昌伸; 水野 成夫; 田中 邦喜

doi:10.1248/yakushi1947.107.11_858

Synthesis of 3-Arylamino-2-dialkylaminomethyl-4, 4-dimethyl-2-buten-4-olides and Their Aza Derivatives

KEIZO MATSUO, MASANOBU OHTA, SHIGEO MIZUNO, KUNIYOSHI TANAKA

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Keywords: tetronic acid, tetramic acid, Mannich reaction, analgesic activity, antimicrobial activity, 3-arylamino-2-dialkylaminomethyl-4, 4-dimethyl-2-buten-4-olide

JOURNAL FREE ACCESS

1987 Volume 107 Issue 11 Pages 858-862

DOI https://doi.org/10.1248/yakushi1947.107.11_858

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Abstract

3-Arylamino-2-dialkylaminomethyl-4, 4-dimethyl-2-buten-4-olides and their aza analogs were synthesized from 5, 5-dimethyltetronic acid and tetramic acid, and tested analgesic and antimicrobial activities.

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