Study on Insulin-Like Efficacy and Insulin Release Activity of Meat, Fishes and Shellfish in Vitro. I

Abstract

The insulin-like effects and the promotions of insulin release of hot-water extracts from various kinds of flesh, including meat, chicken, fishes and shellfish were studied in vitro. An examination of insulin-like effect, in which the indicator was the conversion of D-[2-³H]-glucose to lipids in free fat cells of rats, indicated the existence of insulin-like effects in flesh such as Spanish mackerel (Scomberomorus niphonius) and bonito (Katsuwonus pelamis) of Scombridae, in shellfish like abalone (Haliotis gigantea) and shortnecked calm (Tapes philippinarum), and in the flesh and fowl such as pig (Sus scrofa) and chicken (Gallus domesticus). An examination of insulin release promotion effect, in which the indicator was the release of insulin from the isolated Langerhans'islands of the hamster, indicated that flesh, fowl, fishes and shellfish used in this experiment exhibited an effect which promotes the release of insulin.