Abstract
The effect of saikokeishi-to (SK) on the pharmacokinetics of phenytoin in rabbit was studied. After 10 d-administration of chronic SK to rabbit, total plasma clearance (CL) of phenytoin increased and terminal phase half-life (T1/2, β) decreased significantly. On the other hand, volume of distribution at steady-state (Vss) and protein binding of phenytoin in the plasma did not change between before and after SK treatment. And SK treatment also increased CL of antipyrine by 31%. These results suggested that SK treatment induced hepatic drug-oxidizing enzyme.
