抗潰瘍剤の合成研究(第4報)Dihydrobenzofuranone誘導体の合成と抗潰瘍作用

北沢 牧雄; 赤羽 増夫; 中野 泰志; 早川 和秀; 佐藤 和明; 小林 通洋

doi:10.1248/yakushi1947.109.4_232

Studies on the Synthesis of Antiulcer Agents. IV. Synthesis and Antiulcer Activity of Dihydrobenzofuranone Derivatives

Makio KITAZAWA, Masuo AKAHANE, Yasushi NAKANO, Kazuhide HAYAKAWA, Kazuaki SATO, Michihiro KOBAYASHI

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Keywords: antiulcer activity, dihydrobenzofuranone, acrylic acid, spiro compound, structure-activity relationship, amide

JOURNAL FREE ACCESS

1989 Volume 109 Issue 4 Pages 232-240

DOI https://doi.org/10.1248/yakushi1947.109.4_232

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Abstract

The derivatives of 3-[3-oxospiro [benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acrylic acid (8) were synthesized and tested for antiulcer activities. As a result, 1-[3-[3-oxospiro-[benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acryloyl] piperidine (3t) and 4-[3-[3-oxospiro [benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acryloyl] morpholine (3u) exhibited potent antiulcer activities.

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