YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Enzymes Involved in Metabolic Activation of Carcinogenic Chemicals and Their Hormonal Regulation
Yasushi YAMAZOE
Author information
JOURNAL FREE ACCESS

1992 Volume 112 Issue 10 Pages 679-692

Details
Abstract
Mechanisms of metabolic activation of carcinogenic chemicals, especially arylamines, are discussed together with characteristics of enzymes involved in the activation in the liver and extrahepatic tissues. In rodents, drug and carcinogen metabolizing activities often show clear age-and sex-related differences and also vary in diseased states. The current understanding of the roles of pituitary growth hormone and thyroid hormone on changes of hepatic drug metabolizing enzymes is shown in relation to the developmental changes and alteration in patho-physiological conditions.
Content from these authors
© by the PHARMACEUTICAL SOCIETY OF JAPAN
Next article
feedback
Top