Synthesis and Antimicrobial Properties of 3-O-Alkyl and 3-O-Haloalkyl-D-glucoses

Abstract

A series of 3-O-alkyl and 3-O-haloalkyl-o-glucoses were prepared from 1, 2 : 5, 6-di-O-isopropylidene-α-D-glucofuranose and their antibacterial activities were evaluated. The compounds with C₁₂ and C₁₄-alkyl chains were the most effective in vitro antibacterial screening, among 3-O-alkyl and 3-O-haloalkyl derivatives. The 3-O-alkyl derivatives were more effective than 3-O-haloalkyl derivatives.