1951 Volume 71 Issue 1 Pages 39-40
The synthesis of 2-amino-5-chloro-pyrimidine by the condensation of malondialdehyde and guanidine was carried out with the use of chlorosulfonic acid as the condensation agent. This seems to give a better yield compared to the known method, as well as having the advantage of the reaction proceeding at a room temperature, without the application of heat.