Electrochemical Studies of Acyl Migration of Chloramphenicol Derivatives

Abstract

Electrochemical studies were made on the acyl rearrangement from oxygen to nitrogen in compounds of chloramphenicol series. As a means of dynamic study of this rearrangement, potential titration was found to be suitable, through which it was learned that the acetyl group easily underwent rearrangement in the presence of sodium hydroxide, but that the dichloroacetyl group refused to undergo such arrangement and finally decomposed as dichloroacetic acid.