1954 Volume 74 Issue 5 Pages 495-497
By heating phenol and anisole with free carboxylic acids, in the presence of polyphosphoric acid, for 5-30 minutes in boiling water bath, 4-hydroxy- and 4-methoxyacylophenones were respectively obtained. The present method has made it possible to prepare 4-hydroxyacylophenones quite easily from phenol and carboxylic acids instead of the various indirect methods practiced to date.