Abstract
A kind of coumarin derivative was isolated from the ether extract of the root of Angelica schishiudo Koidz. This substance comes as white needle crystals of mp 130°, C16H16O5, and forms acetone and acetyl-5, 7-dimethoxycoumarin, C13H12O5, with 30% potassium hydroxide, phloroglucinol by alkali fusion, and 5, 7-dimethoxycoumarin with conc, sulfuric acid. The dihydro compounds affords 5, 7-dimethoxycoumarin and isovalerianic acid with conc. sulfuric acid. This substance and the alkaline degradation products give negative Emerson and Gibbs reactions, that it is assumed to possess the side chain in the 6-position. From these evidences, this was assumed to be a new substance, was named angelicone, and a structure of 5, 7-dimethoxy-6-(3, 3-dimethylacryloyl) coumarin (I) is proposed for it. Further, distribution of angelicone in the allied plants was examined by paper chromatography and the results are given in Table II.
