Physicochemical Studies on Antibiotics. VI.

On Equilibrium of Streptomycilideneisonicotinylhydrazine in Aqueous Solutions

Abstract

In an aqueous solution, streptomycilideneisonicotinylhydrazine (Streptohydrazid) exists in an equilibrium of streptomycin and isonicotinic acid hydrazide (INAH). This equilibrium constant differs according to the pH of the solution, the value decreasing with increasing value of pH. This indicates that the equilibrium exists between streptomycin, INAH, and Streptohydrazid and that the difference in their concentration results in different dissociation of each compound and the original and product systems according to pH.