Studies on the Change of Thioacetazone in vivo. VI

On the Administration of Thioacetazone with Pharmaceutical Preparation of Bacteria and Enzymes

Abstract

It was surmised from the preceding work that lactobacilli preparations would also effect deacetylation of thioacetazone. Therefore, deacetylation of thioacetazone was examined with commercial preparation, “Lactomin powder, ” and it was found that the rate of deacetylation was very slight, as shown in Figs. 1 and 2. However, taking of “Lactomin powder” would effect increase of lactobacilli in the intestines and the deacetylation of thioacetazone would probably increase, which suggests that these two drugs should not be used together. Examination of the concurrent use of diastase and medicinal yeast with thioacetazone was also examined but these were found not to affect thioacetazone.