Syntheses of Xanthene Derivatives having Antispasmodic Action. I

Syntheses and Antispasmodic Actions of Alkamine Esters of 9-Xanthenylacetic Acid

Abstract

Seven kinds of alkamine esters of 9-xanthenylacetic acid, obtained by the condensation of 9-xantheriol with malonic acid in pyridine, and an alkamine ester of 9-xanthenylcyanoacetic acid, were prepared. 2, 7-Dinitro-9-xanthenol does not undergo condensation with malonic acid and forms 9-acetoxyxanthene compound on heating with acetic anhydride. Comparative examinations were made on the toxicity, antiacetylcholine, antihistamine, and anti-barium chloride activities of these alkamine esters. In general, these compounds had stronger antiacetylcholine activity than other activities and this action was the strongest in 2-diisopropylaminoethyl 9-xanthenylacetate hydrochloride.