Synthetic Studies on Fungicidal Agent. XIII

New Substitution of Thioanilide-type Compounds. (2)

Abstract

The substitution reaction confirmed in thiopicolinanilide was examined in N-phenylthioisonicotinamides, thiobenzanilides, and thioacetanilides, in order to extend the range of this reaction. It was thereby found that this substitution reaction is not instigated by the effect of nitrogen atom in the pyridine ring but is a general reaction for thioanilide-type compounds. Examinations were also made to see if this reaction also occurs in oxaanilide-type compounds, having oxygen atom in place of sulfur atom, but the substitution reaction was found not to occur in the case of phenylacetanilides, benzanilides, picolinanilides, and acetanilides. It follows, therefore, that this is a substitution reaction characteristic to thioanilide-type compounds.