Abstract
In continuation of previous work, pharmacological action of N-alkyl-1, 5-dimethylhexylamine derivatives was examined. The compounds of this series showed no great difference in their action on blood pressure and antispasmodic effect, all the compounds effecting lowering of blood pressure, but their activities were comparable to or weaker than that of diphenhydramine. Structure-activity relationship indicated the great significance of N-alkylation, as in the case of aralkylamines. In antispasmodic effect, the compounds were comparable to ephedrine in both anti-acetylcholine and anti-histamine activities, and the effect of N-alkylation was not so marked as on blood pressure. The compounds showed various degree of activity in the lowering of capillary peameability and iso-type compounds with 3-5 carbon atoms alone were effective. Hypotensive action of N-isopropylated compound (No. 4) is generally inhibited by cardiotonic drugs but, differing from isoproterenol, this action was not inhibited by dichlorisoproterenol, or rather it was fortified. This compound (No. 4) was slightly antagonistic to atropine and was antagonistic in both acetylcholine and histamine.
