Studies on α-Aminophenylacetic Acid Derivatives having Antispasmodic Activity and their Related Compounds. II

Ester of N-Substituted 2-(p-Methoxyphenyl)glycine and 2-Phenylalanine, and Other Related Compounds of Ester of N-Substituted 2-Phenylglycine

Abstract

A series of alkyl esters of N-(2-diethylaminoethyl)-2-p-methoxyphenyl)glycine and N-(2-diethylaminoethyl)-2-phenylalanine were synthesized by the condensation of α-monosubstituted amino acid ester and 2-chlorotriethylamine. Ethyl 2-phenyl-5-diethylaminovalerate and ethyl (2-diethylaminoethoxy)phenylacetate were prepared to compare their antispasmodic activity with that of the foregoing esters. Some of these esters showed 1-5 times greater spasmolytic activity than papaverine.