Studies on Naphthalenealkylamines for Medical Purpose. II

Syntheses and Pharmacological Actions of N-Alkyl (or Aralkyl)-N-methyl-2-naphthalenealkylamines

Abstract

N-Alkyl (or Aralkyl) derivatives of N-methyl-2-naphthaleneëthylamine (Ia) and N-methyl-2-naphthalenepropylamine (IIa) and their methiodides were synthesized. Tertiary amines (I and II, b-j) obtained and their methiodides were tested for atropine- and papaverine-like activities by the Magnus method, and the relationships between the structures and pharmacological activities were discussed.