Studies on Tertiary Amine Oxides. XXVIII. : Syntheses and Reactions of 2-Chloro-, 2-Bromo-quinoline 1-Oxides and -lepidine 1-Oxides

Abstract

2-Halogenoquinoline 1-oxides were prepared in comparatively good yield by the use of permaleic acid as the N-oxidation agent, making it possible to obtain compounds which had hitherto been difficult to prepare. 2-Chloro-and 2-bromo-quinoline 1-oxides and 2-chloro-and 2-bromo-lepidine 1-oxides were prepared by this method. Several kinds of 2-substituted quinoline 1-oxides were prepared by the reaction of 2-chloroquinoline 1-oxide and lepidine 1-oxide with various nucleophilic reagents.