1966 Volume 86 Issue 9 Pages 861-864
Antibacterial action against human tubercle bacillus, was tested with 23 kinds of indole-3-carboxaldehyde derivatives, including 4-alkylthiosemicarbazones, 4-arylthiosemicarbazones, benzoylhydrazones, and amidinohydrazone hydrochlorides. The microorganisms tested were sensitive strain of H37Rv and heavy resistant strains resistant to 300 γ/ml. of streptomycin, 50γ/ml. of p-aminosalicylic acid, and over 50γ/ml. of isonicotinic acid hydrazide. While the control INAH inhibited the growth for 4 weeks at 0.25 γ/ml. and TBI at 50 γ/ml., most of the compounds tested inhibited the growth at 25 γ/ml. concentration. Therefore, there seemed to be none with excellent antibacterial activity but these compounds were found to have bacteriostatic activity in vitro two times stronger than that of TBI.
