Studies on Chemotherapeutical Drugs. III. : Synthesis of Nitrofuran Derivatives. (2). : Preparation of (5-Nitro-2-furyl) vinyl Derivatives and their Antibacterial Activities.

Abstract

Starting with alkyl 5-nitro-2-furan acrylimidate hydrochloride (II), N-acetamido-(5-nitro-2-furyl) acrylimidic acid (IV) (Table I), 2-[2-(5-nitro-2-furyl) vinyl]-(5-substituted)-1, 3, 4-oxa (or thia) diazoles (V) (Table II), 2-[2-(5-nitro-2-furyl) vinyl]-(5-substituted)-benzimida (or oxa, thia) zoles (VII) (Table III), and other derivatives (IX, X) (Table IV) were synthesized. Antibacterial action of these derivatives in vitro was examined and the results are listed in Table V.