Studies on Heterocyclic Compounds. VI : Methy1ation of Purine Derivatives in N, N-Dimethylacetamide

Abstract

Isoguanine, 2, 6-dimethylpurine, 9-methyl- and 9-cyclohexylguanine, guanine, and xanthine were methylated in N, N-dimethylacetamide, and the reaction products were identified by UV spectrophotometry and paper chromatography. 6-Aminopurines gave 3, 9-dimethyl derivatives regardless of the substituent at the 2-position. 7, 9-Dialkylpurine betaines were obtained when xanthine, guanine, and 9-alkylguanines were treated with methyl p-toluenesulfonate.