Quinoxalines. X. : On the Reaction of 2-(Methylsulfonyl) quinoxaline with Ketones

Abstract

Reaction between 2-(methylsulfonyl) quinoxaline (I) and ketones in the presence of sodium hydroxide was examined. Ketones used were acetophenone (IIa), propiophenone (IIb), diethyl ketone (IIc), acetone (IId), methyl ethyl ketone (IIe), methyl propyl ketone (IIf), methyl isopropyl ketone (IIg), methyl isobutyl ketone (IIh), and cyclohexanone (IIi). Results of the reaction and products formed are summarized in Tables I, II, and III. Difference from earlier experiments on 1-(methylsulfonyl)-4-phenylphthalazine) and ketones already reported was as follows : 1) In the case of straight-chain ketones, only methyl ketones reacted and not ethyl ketones. 2) With the exception of IIa, reaction with methyl ketones resulted in the formation of a compound formed between one mole of the ketone and two moles of I, i.e.1, 1-di (2-quinoxalinyl)-2-propanone.