Studies on Indole Derivatives. V. : Reaction of 3-Methylthio-3-(3-indolyl)acrylic acid Derivatives with Some Amines

Abstract

From the reaction between the methylthio group of 3-methylthio-3-(3-indolyl) acrylic acids (I) and various amines, the corresponding amine derivatives (II) were easily obtained (Table I). In the reactions between I with hydrazine hydrate, acetamidine, or guanidine, cyclization occurred concurrently with substitution and the corresponding indolylpyrazoles (III) and indolylpyrimidines (IV) were produced.