Studies on Compression of Powders. IV. : Discussion on Occurrence of Capping

Abstract

Ethoxybenzamide is commonly used as an antipyretic and analgesic agent. Capping occurs to pure ethoxybenzamide tablets when compressed with high pressure. This phenomenon was examined by measuring the variation in the "stress relaxation rate constant" of compressed powder and that of the "momentary rate of recovery in resiliency of the tablet" in relation to the increased pressure. As a consequence, it was considered that the tendency of the tablet to recover resilience with increased pressure was a potential factor in the phenomenon of capping, which is considered to be caused directly by the destruction, at the second "packing state, " of combination of the powder particles completed at the first "structure fixed state."