Synthesis of α-Bismethylthiomethylene-2-pyridineacetonitriles and Their Reaction

Abstract

2-Pyridineacetonitriles (I) were derived to their sodium salts and reacted with carbon disulfide and dimethyl sulfate to prepare α-bismethylthiomethylene-2-pyridineacetonitriles (II) (cf. Table I). II reacted with amines to form III, IV, and V (cf. Table II). Reaction of I and methyl 1-cyano-2, 2-dimethylthioacrylate (IX) gave 2-methylthio-3-cyano-4H-quinolizin-4-ones (XI)(cf. Table III). XI reacted with various amines to form XV (cf . Table V).