Effect of Long Term Administration of Insect-Metamorphosing Substances on Higher Animals. I

Abstract

Longterm feeding of insect-metamorphosing substances, ecdysterone and cyasterone, slightly increased the growth of mice without any toxicity, when administered in doses of 5-100 μg/day/animal. Daily administration of these steroids even in a dose of 5μg/animal maintained protein synthesis in liver and kidney in an elevated level. Histological examinations of liver tissues after a 90 day administration revealed that metabolism of the cells was activated by ecdysterone and cyasterone.