Uracil Derivatives and Related Compounds. VIII : Synthesis and Anti-inflammatory Activity of Bucolome's Related Compounds (3)

Abstract

As the assumed metabolites of bucolome (I), the compounds (III to VI) formed by the oxidation of 5-butyl to 5-(3-oxobutyl), the compounds (XXI to XXIV) formed by the oxidation of 5-butyl to 5-(3-hydroxybutyl), and the compounds (XXVII and XXVIII) formed by the oxidation of 5-butyl to 5-(4-hydroxybutyl) group were synthesized. At the same time, a series of related compounds were systematically synthesized and the relationship between their chemical structure and their pharmacological action (anti-inflammatory activity) and acute toxicity was examined. XXII was identified as the main metabolite of bucolome by collaborators and details of this work will be published elsewhere.