Studies on Chemotherapeutic Agents Against Mycobacterium Tuberculosis. XXVI. : Synthesis and Antituberculous Activity of Phenylthiourea, p-Ethoxyphenylthiourea and 3-Bromo-4-ethoxyphenylthiourea Derivatives

Abstract

A total of 75 kinds of compounds, comprising 27 kinds of phenylthiourea derivatives, 25 kinds of p-ethoxyphenylthiourea derivatives, and 23 kinds of 3-bromo-4-ethoxyphenylthiourea derivatives, were synthesized and screened for antibacterial activity using sensitive strain of human-type tubercle bacilli H37Rv with Tween-albumin medium, by the in vitro multiple dilution method. Inhibition of bacillary growth by the control agents was found in 0.0313 μg/ml of INH, 0.08-0.156 μg/ml of TBI, 0.313 μg/ml of PAS, and 1.56-3.13 μg/ml of DAT, but none of the synthesized compounds showed better activity, growth inhibition being seen with 3.13 μg/ml of 1-phenyl-3-(4-dimethylaminophenyl)-2-thiourea and with 6.25 μg/ml of 1-phenyl-3-(2-ethylhexyl)-, 1-(4-ethoxyphenyl)-3-(4-bromophenyl)-, 1-(4-ethoxyphenyl)-3-(4-acetylphenyl)-, 1-(4-ethoxyphenyl)-3-(4-butoxycarbonylphenyl)-, and 1-(4-ethoxyphenyl)-3-(2-diphenyl)-2-thioureas.