Iodination of Carnosine and It's Biological Activity

Abstract

Preparation of iodocarnosine and its biological activity are described. Iodocarnosine was proved to be β-alanyl-2, 5-diiodo-L-histidine from its nuclear magnetic resonance spectrum. Iodocarnosine has stronger hypotensive activity than carnosine. Carnosine acts stimulatively on the myocardium while iodocarnosine is inhibitive.