Studies on Anti-atherosclerotic Agents. VII. Experimental Studies of Sodium Chondroitin Polysulfate on Hypolipemic, Anticoagulative, Fibrinolytic and Lipotropic Activities

Abstract

Biological activities were examined on sodium chondroitin polysulfate of low molecular weight, which was obtained from natural chondroitin sulfate-C. Some of them demon-strated lipemia-clearing and anticoagulative activities which were examined in hyperlipemic mice and intact rats, respectively. Sodium chondroitin polysulfate (molecular weight, 4000-6000 ; sulfur content, 13-16%) (CPS) has been selected as having the lowest molecular size with high biological activity. Following results were obtained from pharmacological examinations in view of the antiatherosclerotic activity. 1) Oral Treatment : Hypotriglyceridemia associated with activation of lipopretein lipase was observed acutely in intact and hyperlipemic rats. After a 6-month succesive administation, hypotriglyceridemia was recognized, while normal blood coagulation was observed in intact rats treated with CPS. 2) Intraperitoneal Treatment : Fibrinolytic activity, determined by the time of lysis of euglobulin, is elevated in rats treated with CPS. Further, lipotropic activity of CPS was observed from the experiments on CCl₄-induced injury of rat liver. From these results, characteristic feature of CPS was also discussed with respect to the antiatherosclerotic properties.