Studies on Aromatic Basic Ethers with Antispasmodic Activity. IV. Syntheses and Anticholinergic Activities of Methylsubstituted Phenyl 1-Phenyl-3-piperidinopropyl Ethers

Abstract

Various methyl substituted phenyl 1-phenyl-3-piperidinopropyl ethers were synthesized, and their anticholinergic and mydriatic activities were examined. Phenyl 1-phenyl-3-piperidinobutyl ether methiodide (29), erythro-2-chlorophenyl 2-methyl-1-phenyl-3-piperidinopropyl ether methiodide (48), and 4-tolyl 3-piperidino-1-(3-tolyl) propyl ether methiodide (20) showed potent anticholinergic activities among these synthesized compounds.