Antibacterial Activities of Amidinohydrazones. III. Antibacterial Activities of Alkoxybenzaldehyde and Cinnamaldehyde Amidinohydrazones

Abstract

The relationship between the chemical structure and antibacterial activity of amidino-hydrazones of alkoxybenzaldehydes and alkoqcinnamaldehydes was studied. Although there were a few exception, o-alkoxybenzaldehyde amidinohydrazones showed maximum antibacterial activity with a carbon number of 10, m- or p-alkoxybenzaldehyde amidino-hydrazones with a carbon number of 6 and p-alkoxycinnamaldehyde amidinohydrazones with a carbon number of 5. Antibacterial potency of alkoxybenzaldehyde unsubstituted amidinohydrazones fell in the order of para, meta and ortho. Substitution of -NH₂ with [chemical formula] of amidino moiety in o-alkoxybenzaldehyde amidinohydrazones increased the antibacterial potency against gram-positive bacteria and fungi.