1975 Volume 95 Issue 4 Pages 397-401
Among the 352 kinds of amino acid derivatives obtained from amino acids, N-2-fluorenesulfonyl-β-alanine and N-2-naphthylaminomethyl-L-alanine were found to have a good anti-influenza virus activity. The known antiviral agents had to be given within a short period after viral infection to be effective but these compounds showed a significant effect by administration even 72 hr after viral infection. The action mechanism of these compounds was considered to be the sum of two biphasic effects ; one of inhibiting viral multiplication and the other of inhibiting specific inflammation accompanying viral infection.