Studies on the Constituents of Quisqualis Fructus. III. Synthesis of Quisqualic Acid and the Related Compounds

Abstract

Two synthetic ways to quisqualic acid (I) from 3, 5-dioxo-1, 2, 4-oxadiazolidine (V) and from methyl 3-chloro-2-benzoxycarbonylaminopropionate (X) are described. DL-2-Amino-3-(1-hydroxyureido)propionic acid (DL-II) and L-2-amino-4-(3-hydroxyureido)-butyric acid (VI) were also synthesized.