Studies on Anti-inflammatory Agents. XXXI. Studies on the Synthesis and Anti-inflammatory Activity of Xanthenyl- and Benzopyranopyridinylacetic Acid Derivatives

Abstract

A series of xanthenyl- and benzopyranopyridinylacetic acid derivatives were synthesized by various methods, and the relationship between their structure and anti-inflammatory activity was assayed by the method of ultraviolet erythema. It was thereby found that 2-(5H-[1]benzopyrano[2, 3-b]pyridin-7-yl)propionic acid (IV-2) had the most potent anti-inflammatory activity.