Studies on Diphenyl Ether Derivatives. X. Pharmacological Screening of Dibenzo[b, g][1, 5]thiazocine Oxide Derivatives

Abstract

Pharmacological screening was carried out on newly synthesized dibenzo[b, g][1, 5]thiazocine dioxide derivatives, chiefly for their central nerve action. In the observation of general behavior of rats and mice, these compounds hardly showed a tendency for central nerve suppression, and showed no effect on the grooming to tactile stimuli and acetic acid induced writhing. Anti reserpine activity was seen in a considerable number of the compounds but this activity was fairly weak. Anti tremorine action was seen in a number of these compounds, ED₅₀ values of anti tremorine tremor effect of six compounds with strong activity were measured and the values were compared with those of other anti-parkinsonism drugs. Three compounds with especially strong activity were submitted to LD₅₀ measurements.