Studies on the Alkaloids of Papaveraceous Plants. XXVII. The C₁-units of Corynoline, the Major Alkaloid from Corydalis incisa PERS

Abstract

(±)-Stylopine[N-¹⁴CH₃] methochloride, L-methionine[S-¹⁴C] or DL-methionine-[S-¹³C] was administered by the cotton wick method to Corydalis incisa PERS in May and corynoline (1) was isolated. L-Methionine[S-¹⁴C] and DL-methionine[S-¹³C] were incorporated into corynoline (1) The positions labeled in corynoline (1) were determined to be the methylenedioxy, C-methyl and N-methyl groups by the degradation reaction and ¹H-NMR spectrum.