Studies on Syntheses of Pyrazolone and Pyrazole Derivatives. V : Synthesis of 5-Alkoxy-3-(N-substituted Carbamoyl)-1-substituted Phenylpyrazole

Abstract

5-Alkoxy-3-(N-substituted carbamoyl)-1-substituted phenylpyrazoles (VIII) were synthesized from 5-hydroxypyrazole (IV) by alkylation and amidation. The relationship between their structures and biological activities, such as analgesic or antiinflammatory activities, was assayed by the carrageenin foot edema method and the acetic acid stretching method. Among these compound, 1-(m-chlorophenyl)-3-(N, N-dimethylcarbamoyl)-5-methoxypyrazole (VIII-15) had the most potent analgesic and antiinflammatory activities.