Biopharmaceutical Studies on Pyridinolcarbamate. III. Effect of Continuous Pyridinolcarbamate Administration on Renal Excretion of Phenolsulfonphthalein, p-Aminohippuric Acid, Mannitol and Inulin in Rabbits

Abstract

Continuous administration of pyridinolcarbamate (Pc) significantly decreased the renal excretion of phenolsulfonphthalein and p-aminohippuric acid, which are excreted exclusively by the tubular secretion. On the other hand, continuous Pc administration had little effect on the renal excretion of mannitol and inulin, which are excreted exclusively by the glomerular filtration. These results suggest that the continuous Pc administration competitively inhibits the tubular secretion of some drugs.