Enamino Carbodithioates. III. Methyl 6-Aminouracil-5-carbodithioates. (3). Synthesis and Reactions of 3-Methylthioisothiazolo [3, 4-d]-pyrimidine-4, 6 (5H, 7H)-diones

Abstract

3-methylthioisothiazolo [3, 4-d] pyrimidine-4, 6-(5H, 7H)-diones (IIa, b) were synthesized by treatment with methyl 6-aminouracil-5-carbodithioates prepared by the reaction of 6-aminouracil with carbon disulfide and dimethylsulfate in the presence of alkali, with iodine in dimethyl sulfoxide in a good yield. The reaction of IIa, b with amines, amides, and active methylene compounds gave the corresponding substituted products of methylthio group in II in a good yield.