1979 Volume 99 Issue 7 Pages 779-781
Benzhydryl derivatives of hydroxy- and amino-benzoic acids were synthesized and their biological activities were examined. Among them, 4-chloro-(2), 4-methyl-(4), and 4-methoxy-(5) benzhydrylsalicylic acids and 4-chloro-(7), and 4-methoxy-(10) benzhydryl anthranilic acids showed strong growth-inhibitory effects against Gram-positive bacteria. 4-(4-Methylbenzhydryl)-anthranilic acid (23) also inhibited the growth of Bacillus subtilis. Some of the salicylic and anthranilic acid derivatives were shown to be potent analgesics by the acetic acidstretching method.