Procalcitonin levels and their predictive effect on mortality in Crimean-Congo Hemorrhagic Fever Patients

抄録

Crimean-Congo Hemorrhagic Fever (CCHF) is a potentially fatal disease which is endemic to Turkey. We aimed to investigate the procalcitonin levels and their prognostic value over fatality in CCHF patients. The sera were harvested from the patients who were diagnosed with CCHF within the first two days of the onset of their symptoms. Patients were divided into two groups according to their survival status: fatal or non-fatal. The biochemical and haematological parameters were studied in Biochemistry Laboratory of Sorgun City Hospital. The sera were stored in -80°C until testing for procalcitonin and the procalcitonin levels were assayed by ELISA at Biochemistry Laboratory of Kirikkale University. Forty eight patients were included in the study. Eight of the patients were in fatal group and 40 of them were in non-fatal group. While the procalcitonin levels were high in all patients in fatal group, they were also high in 30 patients of the non-fatal group (75%). The mean value of procalcitonin was 1,12 ng/ml in fatal group and 0,21 ng/ml in non-fatal group (p=0,003). According to the results of our study, procalcitonin levels in the first two days of the onset of the symptoms might be helpful for predicting fatality in CCHF patients.