抄録
Multidrug-resistant Acinetobacter baumannii (MDRAB) colonization increases the risk of spread in the hospital setting. The impact of clinical factors, including antibiotic use, on prolongation of MDRAB colonization has not been investigated. All patients with respiratory tract MDRAB based on culture were enrolled. Long-term colonizers and short-term colonizers were defined as patients whose colonization periods were >30 days or ≤30 days, respectively. Clinical data were abstracted from medical records. MDRAB were isolated in 34 patients. There were 13 long-term colonizers and nine short-term colonizers. Twelve patients were excluded due to loss to follow-up. There were no significant differences in average leukocyte counts, numbers of antibiotic classes used, duration of antibiotic use in 30 days following colonization, or rates of central catheterization or mechanical ventilation between the two groups. Long-term colonizers carried Neisseria species more frequently in the 30 days following colonization than short-term colonizers (7/13 vs 1/9, p=0.01), but not prior to colonization with MDRAB (5/13 vs 1/9, p=0.33). The 90-day MDRAB colonization rates for Neisseria-negative patients and Neisseria-positive patients were 10.0% and 83.3%, respectively (P=0.004). Prolonged MDRAB colonization in the respiratory tract was associated with Neisseria species co-colonization.
