Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years

抄録

Chronic kidney disease (CKD) has been shown to be a poor prognostic factor in HIV patients. This study aimed to find risk factors in HIV-infected patients with early decline renal function or less than 90 ml/min/1.73m². The study was retrospective conducted at Chonprathan Hospital, Thailand. The inclusion criteria were HIV-infected adult patients who were treated at the hospital’s HIV clinic and whose eGFR levels at the first visit had been evaluated. Eligible patients were categorized by eGFR level at 90 ml/min/1.73². Multivariate logistic analysis was performed to evaluate the association of the eGFR of less than 90 ml/min/1.73². There were 301 HIV-infected patients included in the study. Of those, 89 patients (29.57%) had an eGFR of less than 90 ml/min/1.73². Age was the only significant factor associated with an eGFR of less than 90 ml/min/1.73² with an adjusted OR of 1.072 (95% confidence interval of 1.015, 1.132). Age of over 37 years predicted eGFR of less than 90 ml/min/1.73m² in HIV-infected patients with a sensitivity of 80.90% and specificity of 34.91%. Age is independently associated with eGFRs of less than 90 ml/min/1.73² in HIV-infected patients. Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years.