論文ID: JJID.2018.554
Dengue fever (DF) is a mosquito-borne disease and significant global public health problem. Although limited serologic surveys in the literature suggest endemic DF in many parts of Africa, DF cases in Africa are generally underreported due to the lack of diagnostic testing and systematic surveillance, and thus, little is known about the phylogenetic profile of circulating strains. In April 2015, DF was diagnosed in a Japanese national returned from the Democratic Republic of the Congo (DRC). Dengue virus 1 (DENV-1) RNA was detected from the patient’s serum sample by real-time reverse transcription PCR. Phylogenetic analysis of the E gene found that the detected DENV-1 strain was classified in genotype V and closely related to that of the 2013 DF epidemic in Angola, which is located directly south of DRC, with 100% nucleotide identity. This is the first report to characterize the circulating DENV strain in DRC, and indicates that the epidemic DENV-1 strain in Angola in 2013 was also circulating in DRC in 2015.
