IN VITRO EXPERIMENTS ON THE TUBERCULO-BACTERIOSTATIC ACTIVITY OF O-AMINOPHENOL, P-AMINOSALICYLIC ACID, STREPTOMYCIN AND TIBIONE IN THE PRESENCE OF P-AMINOBENZOIC ACID

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It has been known already that the antituberculous activity of p-aminosalicylic acid is antagonized by p-aminobenzoic acid (PABA) (1, 2, 3) . On the other hand, the antituberculous activity of streptomycin and tibione is said to be unaffected by PABA, (4) . Since Okamoto and his coworkers described the antimycobacterial properties of o-aminophenol, this compound has undergone laboratory and clinical investigation (5, 6, 7, 3, 9, 10) . The purposes of the experiments described in this paper are to show that PABA and anthranilic acid do not affect the activity of o-aminophenol. In addition, experimental results bearing on the influence of PABA on the activity of streptomycin, p-aminosalicylic acid and tibione will also be presented.