A Study of New Synthetic Reaction for Industrial Production: A Synthetic Route to Cephamycins (7α-Methoxycephalosporins)

Abstract

We had studied a new synthetic route to 7α-methoxycephalosporins, and completed in the first half of the 1980’s. The synthetic route was adopted for the industrial process of cefminox, a cephamycin-group antibiotic, which had been developed by Meiji Seika Kaisha and was launched in 1987. In this article, the process of the study to the success including attempts not to succeed was described in detail.